Neuro Pathology Glossary

Histochemical stain that selectively demonstrates myelin in nervous tissue. Stains myelin blue-green and is often combin...

A rare primitive neuroectodermal tumor characterized by neural tube-like rosettes and typically occurring in young child...

Rare variant of medulloepithelioma containing striated muscle differentiation, classified as an embryonal tumor.

A typically benign tumor arising from the meninges (protective membranes around the brain and spinal cord).

Epigenetic silencing of the DNA repair gene MGMT, serving as a predictive biomarker for alkylating agent chemotherapy re...

Focal accumulation of activated microglia around sites of neuronal loss, indicating acute tissue injury or inflammation.

Small focal bleeding in brain tissue, typically less than 2mm in diameter. Often associated with cerebral amyloid angiop...

Pathological increase in small blood vessels with endothelial hyperplasia, a defining feature of glioblastoma.

The superficial layer of cerebral cortex containing few cell bodies but numerous dendrites and synapses.

Subspecialty integrating genetic and molecular analysis with traditional histopathology for brain tumor diagnosis.

Extracellular amyloid-beta deposits surrounded by dystrophic neurites, a defining pathological feature of Alzheimer's di...

Intracellular aggregates of hyperphosphorylated tau protein found in neurons, characteristic of Alzheimer's disease.

A benign peripheral nerve tumor composed of Schwann cells, fibroblasts, and perineural cells, often associated with neur...

Brain neoplasm composed predominantly of mature neuronal cells, often with mixed glial components.

Phagocytosis of neurons by activated microglia or macrophages. Indicates ongoing neuronal death and tissue cleanup.

Systematic microscopic and macroscopic evaluation of nervous system tissue to diagnose disease. Encompasses gross examin...

The dense network of neural processes (axons, dendrites) between cell bodies in brain tissue.

Discrete areas of preserved neuropil surrounded by areas of tissue loss or gliosis. Characteristic finding in certain ne...

Abnormal tau-immunoreactive processes in the neuropil, representing a pathological hallmark of Alzheimer's disease and r...

A brain tumor arising from oligodendrocytes, characterized by 'fried egg' cellular appearance and calcifications.

The thick outer membrane covering the brain and spinal cord, consisting of the dura mater.

A neuroendocrine tumor arising from paraganglia, characterized by nesting pattern and chromaffin reaction.

Enlargement of neuronal cell body cytoplasm, often indicating cellular stress or acute injury. May be accompanied by chr...

Specialized extracellular matrix structure that surrounds certain neurons, particularly involved in synaptic plasticity...